at least 的意思是“至少”

例句：

　1."I'm beginning to think you have at least a trace of talent. "

　我现在认为你起码是有些才华的。

　2.There are at least three ways out of that difficulty.

　解决这个问题至少有三种方法。

　3.These shoes will wear at least a year.

　这双鞋至少可穿一年。

in the least的意思是“一点,丝毫”

　例句：

　1.They all agreed that the little man had done quite right; they all said that they didn't blame him in the least.

　大家一致认为小个子做得对，都说他们一点儿也不责怪他。

　2.The fire in the grate looked impish-demoniacally funny, as if it did not care inthe least about her strait.

　壁炉里的残火，张牙怒目，鬼头鬼脑，仿佛表示对于她的窘迫，丝毫都不关心。

　3.She did not in the least miss him.

　她对他一点也不觉得难舍难分。

　4.It would not contribute in the least if we were to besmear each other all over with butter and honey.

　即使我们在身上都涂满牛油和蜜糖也无济于事。