lots of 和 a lot of都是“很多”的意思。

1、a lot of和lots of都可用来修饰可数或不可数名词，而动词应用单数或复数形式，则看名词而定，和a lot或lots无关。

例如：

A lot of/Lots of money was lost.（损失了很多钱。）

A lot of/Lots of people were wounded.（很多人受了伤。）

2、many/much和a lot of/lots of意思相同，但语气上，many和much没有a lot of那么随便。a lot of又没有lots of那么随便。所以，a lot of / lots of不宜用于谨严的写作，多见于口语。lots of和a lot of可以当做定语，即当做many或much那样来使用。

因此，谓语动词的数不是依据lot和lots来决定，而是依据of所引导的名词的数来决定。

如：(a lot of=much)A lot of people have been present.已有许多人到了。

（a lot of=many）There is lots of time to spare.时间绰绰有余。(lots of=much)

many用来修饰复数可数名词，表示许多的意思，与few（少数）的意思相反。而much则用来修饰不可数名词，表示量或是程度，与little（少量）的意思相反：

如：How many people are there in your family? 你们家有几个人？

How much money did you spent on it? 你在这上面花了多少钱？

many和much都可以与more连用，但区别在于many more之后接复数名词，much more之后接不可数名词。

如：There have been many more burglaries this year.今年盗窃案比过去多好些。

His car cost much more money than mine.他的小汽车所花的钱比我的多得多。

much可以用在形容词、副词的比较级之前，但是many不可以。

如：Many of them were very tired.I don't eat much for lunch. 〔代名词)

He is much taller than I. (副词〕